PROTECTIVE EFFECTS OF COCCINIA GRANDIS LEAF EXTRACT: BEHAVIOURAL, ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND HISTOLOGICAL FEATURES OF DIABETIC NEUROPATHY
AbstractPresent study aimed to evaluate the nociceptive, neuro-muscular coordination, electrophysiological, biochemical, and histological features of diabetic neuropathy in streptozotocin-induced diabetic rats and the protective effects of Coccinia grandis leaf methanolic extract. Coccinia grandis (200 mg/kg per day) was given to diabetic rats for 3 weeks. Metformin (150 mg/kg body weight) was used as standard reference drug. Coccinia grandis showed its protection against allodynia test. NCV was also attenuated by treatment of Coccinia. The significant decrease in AR shows its protection against diabetic complications. Histological alterations induced by diabetes in the sciatic nerve were restored with Coccinia grandis leaf extract treatment. These results suggest that Coccinia grandis has attenuated progression of diabetic neuropathy in STZ-induced diabetic rats.
Article Information
27
4302-4309
690
1081
English
IJPSR
B. Nagilla and K. P. Reddy *
Neurobiology lab, Department of Zoology, University College of Science, Osmania University, Hyderabad, Andhra Pradesh, India.
bhaskar.nagilla10@gmail.com
27 March 2014
21 May 2014
15 July 2014
10.13040/IJPSR.0975-8232.5(10).4302-09
01 October 2014
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