ANTILITHIATIC ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF DALBERGIA SISSOO LINN. ETHYLENE GLYCOL INDUCED LITHIASIS IN RATS

Aim of the Study: The aim of this study was to investigate the antilithiatic activity of ethanolic leaves extract of Dalbergia sissoo Linn. ethylene glycol induced in rats. Materials and Methods: All the chemicals were analytical grade. Cystone was obtained from from Himalaya Health Care Ltd. The ethanolic extract of plant Dalbergia sissoo Linn. leaves were given with tween 80 as vehicle administered orally. All chemicals were used of analytical grade available; ethylene glycol was obtained from Merck Ltd., Mumbai, India. Male Albino rats of wistar strain weighing between 150-200 g were selected for the antiurolithiatic activity. Animals were housed in polypropylene cages with the filter tops and maintained at 25 ± 2 ºC, relative humidity 55 ± 10% under controlled conditions of 12-h light: 12-h dark cycle. Results: In the present in-vivo study DSEE (at 100 and 200 mg/kg) exhibited a dose dependent significant anti-lithiatic activity on treatment. The extract dose of 100 mg/kg also caused reduction of calcium, oxalates, phosphorus and creatinine in blood serum level the results were found statistically significant. The antilithiatic effect of ethanol extract at was found significant than the reference standard. Conclusion: The ethanolic extract of Dalbergia sissoo linn. has protective effect against ethylene glycol, induced in rats.