SYNTHESIS, CHARACTERIZATION, INDUSTRIAL APPLICATION AND ANTICANCER ACTIVITY OF NEW N-MUSTARD SUBSTITUTED COUMARIN DERIVATIVES
AbstractA series of N-mustard substituted coumarin have been synthesized characterized and evaluated for their in-vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-2-oxo-2H-chromene-3-carbonitrile derivatives. Among these compounds screened, three compounds (ASW-3g, ASW-3f and ASW-3e) showed GI50 range from 80 to 95 µg/ml. All synthesized compounds were characterized by IR, NMR and Mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer activity.
Article Information
59
4946-4949
379
1010
English
IJPSR
A. Barasara *, H. Bhatt and D. Purohit
School of Science, R. K. University, Kasturbadham, Rajkot, Gujarat, India.
ashwinbarasara59@gmail.com
22 February, 2018
24 June, 2018
26 June, 2018
10.13040/IJPSR.0975-8232.9(11).4946-49
01 November, 2018
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