FORMULATION AND EVALUATION OF LIQUID AND SOLID SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF EPROSARTAN MESYLATE
AbstractThe aim of the present study was to improve the solubility and bioavailability of a poorly water-soluble drug in human body, using a solid dispersion technique. Solubility and dissolution rate is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug, Eprosartan by solid dispersion method using Arosil-200 as carrier. The formulations were characterized for solubility parameters, drug release studies and solubility studies, dissolution studies. All the formulations showed marked improvement in the solubility behaviour and improved drug release. The interaction studies showed no interaction between the drug and the carrier. It was concluded that Aerosil-200 as a carrier can be very well utilized to improve the solubility of poorly soluble drugs.
Article Information
39
5333-5338
389
902
English
IJPSR
S. N. Kothawade * and V. M. Pacharne
Department of Pharmaceutics, SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune, Maharashtra, India.
Sachin_kothawade23@rediffmail.com
06 April, 2018
16 July, 2018
03 August, 2018
10.13040/IJPSR.0975-8232.9(12).5333-38
01 December, 2018
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