IMPAIRMENT OF OVARIAN BIOCHEMICAL CONTENTS AND ENZYMES ACTIVITIES DURING POTASSIUM BROMATE (KBRO3-) INTOXICATION IN ALBINO MICE MUS MUSCULUS

Potassium bromate (KBrO₃^–) is a chemical compound commonly used as a oxidizing agent that has been used as a food additive for baking of white bread, bun, pav and pizza bread. Potassium bromate (KBrO₃^–) is mainly known to generate free radicals, which cause oxidative damage to essential cellular macro molecules, leading to cause nephrotoxicity in experimental animals. In this part of experiment biochemical profile i.e. alkaline phosphatase, acid phosphatase and protein content along with ovarian histopathological changes were observed. The animals were treated with KBrO₃^–, 0.7 mg/g b.wt. in 0.125 ml distilled water orally through canulla upto 15 and 30 days. It has been observed significantly lowered ALP, protein and ACP level elevated. However ovarian histophathological changes were not observed after 15 days KBrO₃^– treatment. Along with the ovary treated with potassium bromate upto 30 days show degenerative cells in the thecal layer and less amount of cytoplasmic was noticed. Our result conclude that in a very low amount, potassium bromate if is available in the body may pose transitory reproductive disruption and are dependent upon the dose and durations employed.