PREPARATION AND EVALUATION OF MICROSPHERES OF FLURBIPROFEN

Microsphere drug delivery systems have used to improve patient compliance, decreases toxicity, and increase efficacy. Also, the use of microspheres to deliver drugs has many other merits, like control-release of the drug, increase bioavailability and target delivery of the drug to the desired site. In this research shows the utility of encapsulating hydroxypropyl methyl cellulose (Methocel K4M) in biodegradable microsphere delivery system, to be delivered orally via a capsule, to gives desired therapeutic action. Microsphere formulations have advantage over conventional tablet or capsule formulations, since it increases the surface area exposed to the absorption site and thus increasing the absorption of the drug and decreasing the dosing frequency of the drug. Flurbiprofen is a non-steroidal anti-inflammatory agent which is used widely in various colon diseases ulcerative colitis, Crohn’s disease, carcinomas and infections. Flurbiprofen shows maximum absorption in the lower gastrointestinal tract regions, and shows half life 4 – 5 h, it shows low bioavailability orally. The microsphere formulations were evaluated for its production yields, actual drug content, encapsulation efficiency, % Swelling Index release study is done by in vitro release analysis.