DESIGN AND DEVELOPMENT OF ANTI-DIABETIC TABLET FORMULATION CONTAINING SPRAY DRIED EXTRACT OF MULBERRY LEAVES

Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia in diabetes is associated with long term damage, dysfunction, failure of kidney, nerves and blood vessel. Nowadays, herbal treatments available for diabetics are eroding the share of allopathic formulations. Currently, the spray drying technique has been widely used for improving processability, biopharmaceutical performance as well as modifying the physical form of various phyto-extracts. Extract of mulberry being sticky may find difficulty in its formulation to tablet dosage form. Across the world, mulberry has been used for its medicinal importance. Looking at its availability and medicinal prospects spray dried mulberry extract was prepared and which is finally assembled into a tablet dosage form. Inert excipients are used to deal with processability, amorphous form and bioavailability issues. Spray drying of the mulberry extract was carried out by using carrier maltodextrin. Results obtained shows excellent/good flowability, compressibility, and compatibility. The dissolution profile of spray dried extract tablet shows a better result. In animal studies, the spray dried extract formulation group had a significant decrease in blood glucose level when compared to the powder formulation group on the 28^th day. Successful completion of this work will revolutionize the herbal market of anti-diabetic formulations available till date. The cost-effective formulation will be available to the patients.