POLYSACCHARIDES FROM ALOE LEAF MUCILAGE AS POTENTIAL IMMUNOLOGICAL-BASED ANTI-FERTILITY AGENTS
AbstractMucilaginous exudates from Aloe leaf containing polysaccharides, of which the major proportion has been reported to be composed of acetylated mannose molecules such as Acemannan and other high molecular weight polysaccharides. These polysaccharides, have been reported to elevate the Granulocyte Macrophage Colony Stimulating Factor (GMCSF) ultimately leading to the infiltration of macrophages at respective sites. This immunological property has been exploited to test the efficacy of dried aloe mucilaginous extract containing these high molecular weight polysaccharides for anti-fertility activity. The polysaccharides were extracted by ethanol precipitation method. The suspension of extract in aqueous medium was prepared under aseptic environment to ensure the desired sterility. Characterization of extract was done by spectrophotometry and IR spectroscopy. The results suggest the presence of biologically active polysaccharides. The preliminary finding of the experiment confirms the anti-fertility activity in rats. However, a mild edema was observed in the uterine horns of the test group animals which subsequently reduced in severity upon reducing the dose. The cause of the oedema could be attributed to the excessive endometrial macrophage infiltration and probably due to the IL-1 stimulation at higher doses
Article Information
58
440-444
537KB
2176
English
IJPSR
Shubhranshu Gupta*, Larissa Pereira, Rohit Dugar and Rajesh Patil
Sinhgad Institute of Pharmaceutical Sciences, Sinhgad Technical Education Society’s, Off Pune-Mumbai Expressway, Kusgaon (bk.), Lonavala, Pune-410401, Maharashtra, India
guptashubhranshu@yahoo.co.in
25 September, 2012; received in revised form, 19 October, 2012; accepted, 29 December, 2012 POLYSACCHARIDES FROM
19 October, 2012
29 December, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).440-44
01 January, 2013
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