EFFECT OF EDAPHIC FACTORS ON MAJOR SECONDARY METABOLITES OF TINOSPORA CORDIFOLIA AND NEEM GUDUCHI WITH RESPECT TO THEIR IMMUNOMODULATORY EFFECT

Tinospora cordifolia is a requisite medicinal plant, has been used for the treatment of various diseases and has been recommended for improving the immune system mentioned in Ayurveda and other systems of medicine as a monoherbal or polyherbal preparation. Nonetheless, Ayurvedic and other ancient literature reported that Tinospora cordifolia growing on neem plant gives better immunomodulatory activity. The traditional and scientific data comprising immunomodulatory potential, pharmacognostic description, therapeutic uses, phytochemical constitution, of Tinospora cordifolia and neem guduchi using the aqueous extract in the form of satwa has well established. The present study evaluates the comparative immunomodulatory activity using satwa of Tinospora cordifolia and neem guduchi using in-vitro models, for understanding the influence of edaphic factors on biologically active compounds. Evaluation of the immuno-modulatory potential of the guduchi satwa and neem guduchi satwa at the dose of 150 and 300 mg/kg body weight was done in rats; assessment of immunomodulatory activity was carried out by assessment of neutrophil adhesion whereas phytochemical profile was established by HPTLC method. Simultaneously, the correlation between soil factors and medicinally active compound responsible for immunomodulation also studied. In the present study, we have compiled and investigated the active compounds which are immuno-modulator. Results of present studies suggested that neem guduchi satwa was found to be potent immuno-stimulant in a dose-dependent manner when compared with other group and there is no clear correlation between soil factors and medicinally active compound were observed.