RECOVERY OF DIMINISHED SPERMATOGENESIS BY RESVERATROL AGAINST THE PYRETHROID, LAMBDA CYHALOTHRIN-INDUCED REPRO-TOXICITY IN ALBINO RATS

Lambda-cyhalothrin [-cyano-3-phenoxybenzyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate] is one of the type II synthetic broad-spectrum pyrethroids used to protect the crops against insects. The aim of the present study was to evaluate the protective effect of resveratrol on male reproductive health in lambda-cyhalothrin exposed rats. Exposure of male rats to lambda-cyhalothrin resulted in a significant reduction in the reproductive organ weights accompanied by a reduction in the testicular daily sperm count and epididymal sperm count, sperm motility, and sperm viability. Further, a significant decrease in the activity levels of superoxide dismutase and catalase with a significant increase in the levels of lipid peroxidation were observed in the testis of lambda-cyhalothrin administered rats over the controls. Moreover, the integrity of testicular architecture was deteriorated in lambda-cyhalothrin exposed rats. Conversely, supplementation of resveratrol enhanced the activity levels of testicular enzymatic antioxidants and inhibited lipid peroxidation levels in lambda-cyhalothrin exposed rats as compared to its respective controls. Significant increase in the selected epididymal sperm variables accompanied by the restoration of testicular architecture was recorded in resveratrol plus lambda-cyhalothrin treated rats over lambda-cyhalothrin exposed rats. On the other hand, no changes were observed in the selected reproductive endpoints in resveratrol administered rats over controls. To conclude, resveratrol could plausibly inhibit lambda cyhalothrin-induced testicular oxidative stress and improves the sperm quality and quantity in rats.drsbsnathbio@gmail.com