FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESION AND FLOATING MICROSPHERES OF ETODOLAC USING IONIC GELATION METHOD

The purpose of this study is to formulation and evaluation of floating and mucoadhesion microspheres of etodolac using ionic gelation method. The floating and mucoadhesion microspheres were studied for micromeritic properties were found to be within limits. The percentage yield of floating microsphere formulation F1 to F6 and mucoadhesive microspheres M1 to M3 were in the range of 77.14 ± 0.64 to 92.74 ± 0.74%. The in-vitro buoyancy of formulation F1 to F6, it was range from 71.96 ± 1.04 to 82.96 ± 1.07. Among all formulation, F6 was found to be highest in-vitro buoyancy 82.96 ± 1.07. The results also showed that the larger the particle size, the longer the floating time. The entrapment efficiency of floating microspheres F1 to F6 and mucoadhesive microspheres were in the range of 77.43 ± 2.72 to 98.11 ± 2.59. Formulations prepared with sodium alginate alone have shown maximum drug release at 12 h in the ratio of 1:3. Formulations prepared with sodium alginate along with HPMC K 4M retard the drug release. Among all formulations of floating microspheres, F3 was considered as optimized for floating microspheres. From the release kinetics data, it was evident that floating optimized formulation follows zero order release kinetics. From the dissolution data of mucoadhesive microspheres by ionic gelation method M1, formulation has shown maximum drug release at 12 h. When an increase in the polymer concentration retards the drug release more than 12 h. Hence, M1 was considered as optimized formulation for mucoadhesive microspheres, and it was followed zero order release kinetics.