IMPROVEMENT IN BIOAVAILABILITY OF POORLY SOLUBLE DRUG BY SELF MICRO EMULSIFYING DRUG DELIVERY
AbstractSolubility is the rate-limiting step for bioavailability of poorly water-soluble drugs. The solubility of poorly water-soluble drugs can be enhanced by incorporating active pharmaceutical ingredients into oral lipid-based drug delivery systems. Self micro emulsifying drug delivery system (SMEDDS) is a researcher’s choice amongst other oral lipid drug delivery systems because it offers advantages like simplicity to manufacture, convenience in scale-up, less interference of food on the dosage form and has the capability to deliver peptides. SMEDDS acts as a drug delivery carrier in which a broad range of different drug moieties can be incorporated. The bioavailability of lipophilic drugs can be significantly increased by formulating in the SMEDDS form. The present review provides a comprehensive summary for types of SMEDDS, manufacturing process, formulations aspects, evaluation characteristics, and patents registered on account of oral lipid drug delivery system.
Article Information
7
3595-3607
613
927
English
IJPSR
A. Shelar, J. Mahore *, S. Deshkar and R. Trivedi
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.
jayashri_mahore@rediffmail.com
26 October 2019
29 February 2020
19 April 2020
10.13040/IJPSR.0975-8232.11(8).3595-07
01 August 2020
Download