FORMULATION DEVELOPMENT AND COMPARATIVE EVALUATION OF TRANSDERMAL DELIVERY SYSTEM FOR EFFECTIVE ANTI-EMETIC THERAPY

Transdermal patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Transdermal patches of dolasetron have prepared by the solvent evaporation method using eudragit RL-100: eudragit RS-100 and ethylcellulose: PVP, using different ratios (8:2, 6:4, 5:5), in solvents like ethanol and methanol (1.25:1.25). The dry films of the prepared patches evaluated for physicochemical parameters such as flexibility, thickness, smoothness, weight variation; moisture content, hardness and tensile strength. The formulation exhibited flexibility, uniform thickness and weight, smoothness, good drug content (92 to 96%) and little moisture content. The in-vitro diffusion studies carried out for the formulated TDD patches followed by the Higuchi diffusion mechanism. The fabricated formulation has identified as ideal formulations depending on their drug release properties on the comparison, at the end of 48 h of the formulations. The formulation is containing eudragit RL-100: eudragit RS-100 (hydrophobic polymers) or a combination of hydrophilic and hydrophobic polymers (ethylcellulose and PVP). The stability studies indicated that all the patches maintained the good physicochemical properties and drug content after storing the patches in different storage conditions. However, the compatibility studies indicated that there has no interaction between the drug and polymers. The higher percentage of drug released in formulations E1, P3 that follows zero-order kinetics (0.940) and Higuchi diffusion equation (0.875). Further, the E1 and P3 formulations have identified as ideal formulations depending on their comparison of the drug release properties.