A STATE OF THE ART REVIEW ON SELF EMULSIFYING DRUG DELIVERY SYSTEM
AbstractSolubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of technical strategies have been investigated for improving bioavailability like solid dispersions, cyclodextrins, micronization, surfactants, nanoparticles, lipids, permeation enhancers, etc. It is a great task for a pharmaceutical scientists to formulate oral dosage forms of these drug candidates with sufficient bioavailability. Among the various approaches to improve the oral bioavailability of these drug candidates, self-dispersing lipid formu-lations is one of the approaches to improve the bioavailability of lipophilic drugs. Self-dispersing lipid formulations is a very broad area that covers self-emulsifying drug delivery system (SEDDS), Self-micro emulsifying drug delivery system (SMEDDS), Self-nano emulsifying drug delivery system (SNEDDS) as carrier systems that have been developed.
Article Information
17
4244-4260
729
627
English
IJPSR
A. Prameelarani, M. Desavathu * and L. S. Reddy
Department of Pharmaceutics, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
madhuridesavathu@gmail.com
30 December 2019
21 March 2020
27 March 2020
10.13040/IJPSR.0975-8232.11(9).4244-60
01 September 2020
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