APPLICATION OF NANOTECHNOLOGY FOR TREATMENT OF ANGINA PECTORIS AS CARDIOVASCULAR DISEASE: A REVIEW

Angina Pectoris is the medical term for chest pain or discomfort due to coronary heart disease. The drawback of the marketed formulation is required repeated administration of the drug due to low bioavailability. Therefore, it utilized a nanotechnology technique for prevention of drawback of marketed formulation. Polymeric nanoparticles have been in preferential list when it comes to nano-drug delivery via oral route. Recent advances in lipid-reducing treatment, statins clinical research suggests that antimicrobial therapy is important to continue reducing cardiovascular events, beyond lipid-reducing therapy. A potential therapeutic choice for the residual risk is to intervene directly in the inflammatory process through a drug delivery system based on the nanotechnologies. Different nano-sized materials, including micelles, liposomes, polymer nano-particles, dendrimers, carbon nanotubes, and metal nanoparticles, are currently developed as by nanotechnology. It is a viable strategy since the inflammatory environment enhances the integration of nano-sized materials into a mononuclear phagocytic process. We have recently developed a polymeric nano pharmaceutical statin in order to optimize its anti-inflammatory properties. In the present review, we present the current development of nanotechnology and future prospects on the treatment of life-threatening cardiovascular disease by anti-inflammatory nanomedicine.