FORMULATION OPTIMIZATION OF BENZYDAMINE HYDROCHLORIDE NANOSPONGES LOADED HYDROGEL FOR TREATMENT AGAINST MOUTH ULCERS
AbstractThis study is aimed at encapsulating Benzydamine Hydrochloride into nanosponges that involve different crosslinkers to polymers in the ratio of 1:1, 1:2, 2:3, etc., which are used, in order to protect these structures, to control their release and maintain their site-specificity. Emulsion Solvent Diffusion technique was applied for the formation of nanosponges, which were incorporated into carbopol hydrogel to give controlled release of the drug so that it adheres for a longer duration to the buccal mucosa and would gradually release the drug to give the desired release. The pre-formulatory DSC and FTIR study indicated there were no interactions of Benzydamine Hydrochloride (BZH) with excipients (Poly Vinyl Alcohol and Poloxamer 188). The formation of these nanosponges is confirmed through DSC, FTIR, FESEM, and TLC studies. BZH was loaded up to 88%, 85%, 72% w/w. Particle sizes of the loaded NS formulations were between 128 and 250 nm with low polydispersity indices of 0.6. Zeta potential was -17 to -150 mV, which gave a stable colloidal nanosuspension. Release studies were optimized by evaluating through different membranes such as the dialysis membrane, cellulose acetate membrane, and excised porcine mucosa. The release of the final formulation was evaluated by the use of permeation enhancers. Obtained nanogel showed controlled release over the conventional preparation to prolonged-release and to decreased the dosing frequency.
Article Information
22
4945-4956
841
602
English
IJPSR
J. Shaji * and T. Vaswani
Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai, Maharashtra, India.
jessy.shaji@gmail.com
25 October 2019
06 February 2020
12 March 2020
10.13040/IJPSR.0975-8232.11(10).4945-56
01 October 2020