A REVIEW OF SOME MEDICINAL PLANTS ON THEIR ANTIULCER AND ULCER HEALING POTENTIAL

The imbalance between aggressive (pepsin, Hydrochloric acid­) and protective elements (bicarbonate and mucosa) in the inner lining of the stomach lead to the formation of peptic ulcers. The presence of Body fluids, mucosal hydrophobicity, fast epithelial cell recharging, and rich mucosal blood flow is involved in mucosal protection of the Stomach. Prostaglandins E2 and I2 are the predominant prostaglandins which synthesized by the gastric mucosa and known to hinder the emission of gastric acid and stimulate the discharge of body fluid and bicarbonate. The treatment of peptic ulcers can either be achieved with declination in aggressive elements or elevation of mucosal resistance in the stomach and duodenum with cytoprotective agents. In this review, 30 herbal medicinal plants have been discussed along with its respective extracts; these are Bauhinea veriegata, Euphorbia umbellata, Azadirachta indica, Centella asiatica, Indigo feratinctoria, Mangofera indica, Moringa oleifera, Mimosa pudica, Aegle marmelos, Lawsonia inermis, Tephrosia purpuria, Plantago lanceolata, Solanum nigrum, Annonas quamosa, Ocimum sanctum, Morus alba, Pinusrox burghi, Allium sativum, Hibiscus cannabinus, Emblica officinalis, Curcuma longa, Zingiber officinale, Withania somnifera, Terminalia arjuna, Asparagus racemosus, Sesbania grandiflora, Ficus religiosa, Spondias mombin, Aerva persica and Feronia elephant. Reduction in raised Glutathione (GSH), Malondialdehyde (MDA), Myeloperoxidase (MPO), Lipid Peroxidation (LPO), Total acidity are some of the mechanisms of action of these medicinal plant observed in indomethacin, pylorus ligation, ethanol, aspirin-induced in-vivo, and in-vitro models. Accordingly, this review provides numerous evidences that show these medicinal plants can be used for the treatment and prevention of ulcer and the related problems.