PEPTIC ULCEROGENESIS: ETIOLOGY, PATHOGENESIS AND VARIOUS CLINICAL ASPECTS

“Eat to live and don’t live to eat” this is a principle to be followed for a healthy and wealthy life. According to the therapeutic point of view, the patient who suffers from peptic ulcer diseases was shown to have a reduced secreted amount of HCl and pepsin. The management of gastric and duodenal ulcers can be followed by the decreased or neutralized level of gastric acid. Peptic ulcer influences up to 10% of the all-out total populace accordingly called chronic disease. Peptic ulcer arrangement relies on the lessening in the mucosal guards and on the nearness of the gastric juice pH. The two central points which disturb the mucosal protection from damage is the Helicobactor pylori (H. pylori) contamination and Non-steroidal calming drugs (NSAIDs). The valuable medicines of peptic ulcer are Proton pump inhibitors, Histamine-2 (H₂) receptor antagonists, Antacids, Anticholinergics, Mucosal defensive agents, Bismuth compounds, Antimicrobial agents, and cholecystokinin-2-receptor antagonists drugs. The review contains the detailed study of H₂ receptor antagonist drugs used as anti ulcers and the recent advancements to cure peptic ulcer disease. To heal the ulcer, the following factors are implied- a strict diet, anti-secretory, and motor-inhibitory drugs, antacids, sedatives, physical and mental rest, and strict prohibition from alcohol and stimulants like alcohol and caffeine-containing products.