GC-MS ANALYSIS AND ANTI-INFLAMMATORY ACTIVITY OF MUREX TRIBULUS
AbstractThe aim of this study was to screen the presence of bioactive compounds through GC-MS analysis and carry out the ant-inflammatory test of the methanolic tissue extract of Murex tribulus, a spiny predatory gastropod that is widespread from the Central Indian Ocean to Western Pacific Ocean. The GC-MS analysis of the methanolic flesh extract revealed the presence of four bioactive compounds, 1, 2 dimethyl hydrazine, urea, cis-9 hexadecenoic acid, and 1, 1, 1, 3, 5, 5, 5 hepta-methyltrisiloxane. Among the compounds identified, 1, 1, 1, 3, 5, 5, 5-Heptamethyltrisiloxane was the most abundant antimicrobial compound (92.87%) present in the methanolic tissue extract of M. tribulus. The results of the GC-MS analysis showed that the bioactive compounds present in the tissue extract showed anti-inflammatory responses. Hence in-vitro anti-inflammatory activity in the tissue extract of M. tribulus was determined by proteinase inhibitory activity and 5-lipooxygenase inhibitory assay. The anti-inflammatory test showed promising results with high percentage of inhibition such as 53.50% at a concentration of 1000 µg/ml in proteinase inhibitory activity and 75.42% at the concentration of 1000 µg/ml in %-lipoxygenase inhibitory assay.
Article Information
29
6184-6188
876
815
English
IJPSR
J. E. Mereen * and J. H. J. Diaz
Department of Zoology, St. Mary’s College (Autonomous), Thoothukudi, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.
esthermereen@gmail.com
04 December 2019
10 October 2020
20 November 2020
10.13040/IJPSR.0975-8232.11(12).6184-88
01 December 2020
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