NON-INVASIVE PRENATAL DIAGNOSIS: A REVIEW
AbstractAneuploidies are one of the important causes of perinatal morbidity and mortality. Initially screening for aneuploidies started with maternal age risk estimation. Later on, serum testing for biochemical markers and ultrasound markers were added. Women detected to be at high risk for aneuploidies were offered invasive testing. Recently, various methods including non-invasive prenatal testing (NIPT) by analysis of cell-free fetal DNA (cffDNA) in maternal blood has shown promise for highly accurate detection of common fetal autosomal trisomies. Incorporating these new noninvasive technologies into clinical practice will impact the current prenatal screening paradigm for fetal aneuploidy, in which genetic counseling plays an integral role. The advantage of the technique being elimination of risks such as miscarriage associated with invasive diagnostic procedures. But then this new technique has its own set of technical limitations and ethical issues at present and further research is required before implementation. Data was obtained through a literature search via Pubmed and Google as well as detailed search of our library database.
Article Information
12
1348-1355
449KB
1822
English
IJPSR
Madhusudan Dey, Sumita Agarwal and Sumedha Sharma
40/ 41, First floor, Momohar kunj, Gautam Nagar, New Delhi – 110049
deym1@yahoo.com
01 January, 2013
30 January, 2013
13 March, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(4).1348-55
01 April, 2013
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