COMPARATIVE STUDY OF THE EFFECTS OF LAURUS NOBILIS AND SYZYGIUM AROMATICUM AQUEOUS EXTRACTS ON URINE VOLUME AND RENAL FUNCTION IN RATS

The purpose of the current study was to investigate the diuretic and renal effect of the aqueous extracts of Laurus nobilis leaves and dried flower buds of Syzygium aromaticum. Four groups of rats were used. Group 1 received distilled water (10 ml/kg BW), group 2 received the aqueous extract of Laurus nobilis (300 mg/kg BW), group 3 received the aqueous extract of Syzygium aromaticum (300 mg/kg BW) and group 4 received furosemide (15 mg/kg BW). The interventions were administered daily for nine days. The urinary volume was measured every day. On day nine, the kidneys were removed for histological analysis, the urine and blood samples were obtained from each rat to analyze urine and plasma potassium, sodium, chloride and creatinine, serum urea, and serum albumin. Renal clearance, saluretic activity, estimation of the carbonic anhydrase inhibition activity, osmolar clearance, plasma osmolarity, free water clearance, free water reabsorption were calculated. The results showed that furosemide and both plants extract produced a significant increase in diuresis, creatinine clearance, and saluretic index, furosemide increase significantly the urinary excretion of Na⁺, K⁺ and Cl^– while both plants increased Na⁺ and Cl^– and a less effect on potassium excretion without causing hypokalemia or changing blood urea, albumin, blood creatinine, urine creatinine, and natriuretic index. While furosemide caused hypokalemia. No alteration was shown in the kidney structure of all groups.