ANTI-DIABETIC EFFECT OF LEAF AND STEM EXTRACT OF MACROTYLOMA UNIFLORUM (LAM.) VERDC IN ALLOXAN INDUCED DIABETIC RATS

Diabetes mellitus (DM) is a metabolic disorder in the endocrine system resulting from a defect in insulin secretion, insulin action or both of them. Adverse side effects of chemical drugs for the treatment of diabetes persuaded the use of medical plants. Macrotyloma uniflorum is a traditionally used plant for the treatment of diabetes is packed with powerful plant constituents with polyphenols, flavonoids, and proteins. They are one of the richest antioxidant sources, which lower blood sugar and bear other beneficial health effects. The purpose of this study is to evaluate the effect of ethanolic extract of Macrotyloma uniflorum leaves and stem (EMULS) on Alloxan-induced diabetic rats. In this study 36 Male Sprague Dawley rats, the body weight of 150-200 g was divided into 5 groups. Diabetes was induced by intraperitoneal injection of 150 mg/kg Alloxan. The Macrotyloma uniflorum treatment duration was 30 days in which two doses of extract (200 mg/kg & 400 mg/kg) were orally administered to diabetic rats. Blood glucose levels were estimated with glucometer before treatment, 2 h and 1-4 weeks after administration of extracts. Treatment with extracts of the Macrotyloma uniflorum resulted in a significant reduction in blood glucose. Extract of this plant is useful in controlling the blood glucose level. Macrotyloma uniflorum appears to aid in diabetes control and diminution of the complications of the disease.