DESIGN, DEVELOPMENT AND EVALUATION OF POLYHERBAL TABLET OF TWO ANTI-ULCER LEAVES

Aim: The present study was to develop and evaluate antiulcer polyherbal tablet as designing of oral herbal formulation. The methanolic extracts of Abrus precatorius (MEAP) and Cordia wallichi (MECW) leaves were used in different concentrations in the formulations. Materials and Method: The current exploration was to design a gastro-retentive drug delivery system of MEAP and MECW using swelling polymer through the wet granulation method. All the formulations were evaluated for weight variation, hardness, friability, drug content, and in-vitro dissolution. In this gastro-retentive dosage form using hydroxypropyl methylcellulose-K₄M was prepared to develop sustain release tablets, which could remain in the stomach for longer periods of time, delivering the drug to the site of action. Results: Pre and Post-compression parameters of all the formulations were within the Pharmacopoeial limits, and in-vitro drug release of F8 formulation was found to be 98.29% in 12 h. Conclusion: Dissolution studies of the composition, it was concluded that the formulation F8, which is containing 200 mg of polyherbal extracts, 140 mg of HPMC-K₄M, 85 mg of MCC, 65 mg of sodium bicarbonate, 5 mg of magnesium stearate, and 5 mg of Talc is the best formulation. F8 possessed a quick buoyancy lag time of 34 s and a maximum total floating time of 12 h. As the consequence of this study, it may accomplish that the floating tablets using HPMC-K₄M are a hydrophilic polymer that increases the gross register tonnage of the dissolution fluid to deliver the drug in a sustained manner.