DEVELOPMENT AND EVALUATION OF GINGER TRANSDERMAL PATCH AND ITS IMPLICATIONS IN MIGRAINE THERAPY
AbstractThe potential of transferosomal formulation for transdermal delivery of Ginger constituents was investigated. The aim was to reduce the dosage and improve patient acceptance. Transferosomes were formulated by ethanol injection technique using Phospholipids (Lipoid P-100), cholesterol, various edge activators (tween 80, Span 80), and other excipients. Transdermal patches were prepared by solvent casting method using polymers (Ethylcellulose, HPMC), penetration enhancers (Oleic acid, Tween 80) and PEG 400 as a plasticizer. Transferosomes were evaluated for in-vitro release, particle size, zeta potential, entrapment efficiency, and stability. Patches were evaluated for folding endurance, uniformity of weight, drug content, and thickness. Transferosomes with 1:2:0.25 ratio of Phospholipid: ginger extract: Tween 80 showed particles of 318.8nm, the zeta potential of -6.3mV and 74.4% entrapment efficiency and 67% in-vitro release. Optimized batch of patches showed folding endurance 7, 0.134 ±0.0012 mm thickness, 97.18 ± 0.78% drug content. Thus, transferosomes with transdermal delivery is a better approach to deliver ginger constituents.
Article Information
43
3366-3374
920
831
English
IJPSR
J. N. Deora and S. S. Patil *
Department of Pharmacognosy, Prin. K. M. Kundnani College of Pharmacy, Mumbai University, Cuffe Parade, Colaba, Mumbai, Maharashtra, India.
drswatispatil@gmail.com
17 June 2020
14 October 2020
04 May 2021
10.13040/IJPSR.0975-8232.12(6).3366-74
01 June 2021
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