A NOVEL APPROACH TOWARDS GREEN SYNTHESIS OF ZINC NANOPARTICLES FROM BANIUM PERSICUM AND ITS PHARMACOLOGICAL EFFICACY

Integration of nano-science in medicine leads to the development of biomedical products that help society in a faster and safer manner. In the present studies, Zinc nanoparticles were synthesized by green synthesis route using aqueous extracts of Banium persicum, and characterization was done through UV, SEM, TEM, FT-IR, and XRD. The synthesized nanoparticle was spherical in shape with an average size of 20 nm. Various bioactive compounds present in aqueous extract of this plant were responsible for bioreduction of nanoparticles. Further, these nanoparticles were tested for various biological activities. In antimicrobial activity maximum, anti-bacterial activity was observed against S. aureus at 120 µg/ml (IZ-18 mm),while in the case of fungus, maximum potential was observed at against C. albigans at 120 µg/ml (IZ- 30 mm). Further nanoparticles were screened for their antioxidant activity by LPO, Peroxidase, and Catalase assay and found they possessed potent antioxidant activity. The platelet aggregation of nanoparticles was assayed by Prothrombin (PT) and Activated Partial Thromboplastin time (APTT). In PT assay, maximum activity was observed at 6 µg/ml (128 sec), and in APTT it was found at 1 µg/ml (478 sec). Results showed the biosynthesis of Zinc nanoparticles using aqueous extract of Banium persicum is a clean, inexpensive and safe method that is free from toxic substance and consequently does not have any side effects.