EXCITOTOXICITY AND CELL DAMAGE – A REVIEW
AbstractExcitotoxicity refers to the pathological process by which nerve cells are damaged & killed by glutamate or related excitatory amino acid under conditions such as after intense exposure. This occurs when receptor for the excitatory neurotransmitter such as N-methyl-D-aspartate (NMDA) or AMPA are over activated. Such excitotoxic neuronal death may take part in the pathogenesis of brain or spinal cord injury associated with several human disease states. Various mechanisms involving excitotoxicity have been proposed to explain the neuronal cell death characteristic of neurodegenerative diseases, including elevation of intracellular calcium, accumulation of oxidizing free radicals, impairment of mitochondrial function and activation of apoptotic programs.
Article Information
5
2062-2066
310KB
1433
English
IJPSR
Saba Shaikh*, Ravi Dubey, Y.M. Joshi and Vilasrao J. Kadam
Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector-8, C.B.D. Belapur, Navi Mumbai-400614, Maharashtra, India
shaikhsaba66@gmail.com
12 February, 2013
30 April, 2013
12 May, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2062-66
01 June, 2013
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