THREE GENERATIONS: PIMARY, SECONDARY AND TERTIARY GENERATIONS OF TRANSDERMAL DRUG DELIVERY SYSTEMS: A REVIEW

From this article, we get the knowledge about the transdermal patch, transdermal drug delivery system and anatomy of the skin. Now-a-days transdermal drug delivery, system is widely used in much disease. So, this article gives the knowledge about pre transdermal system, post transdermal drug delivery system and future of transdermal drug delivery systems and examines the benefits and limitations of current transdermal drug delivery system. We also get information about different drugs’ transdermal patch which was approved by FDA in different years. There is a difference in design of transdermal patch in which mainly design of liquid reservoir system and adhesive matrix system and system how it works. Here in first generation, mainly reservoir system is used, while in second generation mainly iontophoresis and chemical penetration enhancers can be used however in third generation thermal ablation as a penetration enhancer can be used. These all designs include in different generation which shows what is the novel approach occurs as the time gone. So, these guide to basic and modified basic information of transdermal patch. Now a days the the PassPort ® system has also been shown to be effective in transdermally delivering insulin. Phase I clinical trials show that the PassPort ® system was able to deliver a therapeutically significant amount of insulin through the skin, which is a novel approach for treatment of diabetics