SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL TRIAZOLE DERIVATIVES
AbstractTriazole is a diunsaturated heterocyclic compound that contains two nitrogen groups as heteroatoms. In the present study, an attempt was made to synthesize various derivatives of substituted 1, 2, 4-triazol-3-yl) benzene-1-ol and assess their antimicrobial efficiency. The synthesized compounds were subjected to physical characterization and spectral analysis by IR and NMR for structure elucidation. The compounds were then subjected to evaluation of antimicrobial activity against bacterial strains Escherichia coli (Gram -ve), Pseudomonas aeruginosa (Gram -ve), Bacillus Subtili (Gram +ve), Staphylococcus aureus (Gram +ve) method using ciprofloxacin as standard and against fungal strain Aspergillus niger method using fluconazole as standard. The results of antibacterial activity show that compounds P1 and P2 and the results of antifungal activity show that compounds P3 and P4 showed equivalent activity when compared with standard while the rest of the compounds were found to be less active than standard.
Article Information
29
4858-4863
559 KB
449
English
IJPSR
Khushboo Arora *, Sumeet Prachand, Hemant Khambete and Sanjay Jain
Faculty of Pharmacy, Medicaps University Indore, Madhya Pradesh, India.
naik.khushboo@gmail.com
20 April 2020
24 June 2021
23 May 2021
10.13040/IJPSR.0975-8232.12(9).4858-63
01 September 2021
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