FORMULATION AND EVALUATION OF METOPROLOL LOADED SOLID LIPID NANOPARTICLES

The main aim of the present study is to formulate and evaluate solid lipid nanoparticles of Metoprolol. Metoprolol is an anti-hypertension drug used in the treatment of hypertension, angina pectoris, and heart failure. Metoprolol belongs to BCS class-I, which has high solubility and high permeability. The drug needs to be administered frequently (2-3 times a day), and it has side effects and poor bioavailability of 40-50% drug through oral administration. In order to avoid the side effects and to improve its bioavailability and sustained release of the drug, there is a need to develop Metoprolol-loaded solid lipid nanoparticles. In the present study, solid lipid nanoparticles of Metoprolol were prepared by the Hot Homogenization technique. In this solid lipid nanoparticles of Metoprolol, employing Compritol as the carriers and Tween 80, PEG-400 and soya lecithin as surfactant systems and were evaluated for various parameters like entrapment efficiency, drug content and in-vitro drug release, particle size and zeta potential. The C8(1:3) formulation showed better results entrapment efficiency of 98.20%, drug content of 82.10% and 48.16% of drug release for a period of 6 h, particles of the size of 286.7-386.9 nm and zeta potential value of -29.4 mV. The present study demonstrated that Metoprolol can be successfully formulated into solid lipid nanoparticles to improve its bioavailability and sustained release of the drug.