FORMULATION AND EVALUATION OF ANTACID ANALGESIC TABLET

The present study deals with formulation of a combined analgesic and antacid effervescent tablets. Paracetamol is the model drug used. It is poorly soluble in the water and hence the formulation is in the form of an effervescent tablet so that the disintegration time of the drug is not hindering the action. The mixture of magnesium and aluminium hydroxide is used as the model antacid. The present research work describes a combination dosage of the antacid and analgesic which is useful in case of hyperacidity related severe headaches. In the formulation citric acid and tartaric acid along with sodium bicarbonate is being used as the effervescent mixture. It not only aids in solving the disintegration problem but also increases the palatability due to its acidulous taste. It severs advantages of the tablet dosage form and has the bioavailability of that of the liquid formulation. The combination can also be dispensed in the form of granules in unit sachets. The release character was studied using the disintegration and the dissolution studies conducted. The amount of the active available from the dosage after the release was studied using the UV spectrophotometer and also the values of individual assays conducted. The formulation was seen to have good release and availability of both the active moieties.