NEPHROPROTECTIVE EFFECT OF CUMINUM CYMINUM SEEDS EXTRACT ON DIABETIC MICE MODEL

Diabetes mellitus is a metabolic condition characterized by insulin resistance, or poor secretion, or both. There are several side effects associated with drugs available to cure diabetes. The most common side effect is neurodegenerative. The objective of the present research was to evaluate the efficacy of Cuminum cyminum seed against diabetes and also to evaluate its nephroprotective power in the diabetes mice model. Twelve mice were housed, caged, and segregated into three groups for 28 days (four weeks). Control, diabetic control, and diabetic with Cuminium seed treatment. The diabetic mice model was prepared by a single dose of alloxan (110 mg/kg/bw) introduced intraperitoneally. Glucose monitoring and diabetic condition checked and confirmed by a one-touch glucometer. Alcoholic extract of Cuminum cyminium seed (80mg/kg/ body weight) orally administrated to the diabetic group of mice up to 28 days. After the completion of the whole experiment, animals were sacrificed blood samples were collected for the investigation of biochemical parameters, including glucose, urea, uric acid, and creatinine. There were the least changes observed in the control group of mice. But in the diabetic control group value of glucose, urea, uric acid, and creatinine were very high (p<0.0001). After the treatment with ECSE (ethanolic cumin seed extract), a significant reduction was observed in all the above parameters. This study may be concluded that Cuminium cyminium seed has antidiabetic as well as nephroprotective potential.