EVALUATION OF WOUND HEALING ACTIVITY OF LEAF EXTRACT OF DODONAEA VISCOSA JACQ INALLOXAN INDUCED DIABETIC WISTAR ALBINO RATS

The present study was undertaken to evaluate the wound healing activity of leaf extract of Dodonaea viscosa Jacq in diabetic wistar albino rats. Wound is defined as a loss or breaking of cellular and anatomic or functional continuity of living tissue. Normal wound healing response begins the moment the tissue is injured. Wound healing is the process of repair that follows injury to the skin and other soft tissues. For the study, various excision, incision and granuloma pouch models were used. In each model, animals were divided into three groups (n=6). Group I was control group, Group II was treated with silver sulfadiazine and Group III was treated with ointment of Dodonaea viscosa. In excision wound model, the significant (p<0.001) increase in rate of wound contraction was observed. Also, there was increase in rate of reepithelization, matrix density and capillary number. The collagen content was found to increase as compared to control. In incision wound model it was found that there was increase in tensile strength. Cotton pellet model supports the anti- inflammatory activity of Dodonaea viscosa plant The present study suggested that the topical administration of ethanol extract of Dodonaea viscosa in form of ointment plays a major role in diabetic wound healing. Our present documented findings may suggest the use of Dodonaea viscosa to treat diabetic wounds