DESIGN AND EVALUATION OF MUCOADHESIVE BUCCAL PATCHES OF SALBUTAMOL SULPHATE BY USING HUPU GUM AND LANNEA GUM
AbstractThe purpose of the present investigation is to evaluate the applicability of hupu gum and lannea gum in the design of buccoadhesive patches for extended-release over a period of 6 hours, using Salbutamol sulphate as a model drug. The efficiency of these polymers was compared with already established synthetic polymer PEO coagulant. The patches were prepared by using the solvent casting method in which, initially backing layer with cellulose acetate was formed on which patches were cast for unidirectional drug release to buccal mucosa. In-vitro drug diffusion studies were done by using Franz diffusion cells. The kinetics of both the phases were calculated, and both the phases followed zero-order for the majority of the patches. Based on the swelling Index (%), buccoadhesive strength, ex vivo residence time and in vitro diffusion studies SHG9 (hupu gum), SLG9 (lannea gum) and SPEO6 were considered as optimized formulations as they could extend the drug release over a period of 6 hours as contemplated. Among three optimized patches, SHG9 and SLG9 were found to be superior compared to SPEO6 due to significantly higher swelling index, buccoadhesive strength, and ex vivo residence time.
Article Information
36
6488-6497
688 KB
429
English
IJPSR
Anu Pravallika Janipalli *, K. V. Ramana Murthy and Lohithasu Duppala
Division of Pharmaceutical Technology, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.
anuaucops@gmail.com
18 January 2021
10 May 2021
28 May 2021
10.13040/IJPSR.0975-8232.12(12).6488-97
01 December 2021
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