DESIGN AND CHARACTERIZATION OF ACECLOFENAC BIONANOCOMPOSITE USING NATURAL SOLUBILIZERS
AbstractThe objective of the present research is to enhance the solubility and improve the rate of dissolution of poorly water soluble drug aceclofenac, which belongs to BCS class II. Enhancement of solubility was be achieved by converting the poorly water-soluble drugs into Bionanocomposites (BNCs) by using natural carriers, which ultimately leads to enhance the bioavailability of drug entities. Bionanocomposites (BNCs) were prepared using the microwave-assisted synthesis fusion method, where the drug entities were fused with natural carriers such as Acacia arabica and gond katira. Selection of carriers was done based on their wetting and surfactant properties. The FTIR, DSC studies reveal that there was no any interaction between aceclofenac and Natural carriers. Solubility dissolution studies were carried out to investigate the solubility-enhancing property of the BNCs. In-vitro dissolution studies of prepared aceclofenac’s BNCs were characterized through DSC, SEM, XRD and FTIR. Both the gum were shown less % of swelling index, viscosity and foaming index. From the study, it was found that the developed ten batches of BNCs among which aceclofenac: Acacia arabica (1:4) ratio shown highest acceptable solubility i.e. 5.38 mg/ml and % drug release 97.22±1.1 % as compared to aceclofenac: gond katira (1:3) ratio shown acceptable solubility i.e. 4.72 mg/ml with drug release of 85.54%.BNCs of aceclofenac prepared with Acacia arabica provides significant enhancement insolubility and highlights its use in solubility and dissolution enhancement as compared to gond katira.
Article Information
38
6510-6521
1778 KB
352
English
IJPSR
Nitin S. Desai, Sunil T. Galatage *, Swapnil S. Harale, Suresh G. Killedar, Ravindra B. Kumbhar and Arehalli S. Manjappa
Sant Gajanan Maharaj College of Pharmacy, Mahagaon, Kolhapur, Maharashtra, India.
gsunil201288@gmail.com
21 January 2021
29 April 2021
28 May 2021
10.13040/IJPSR.0975-8232.12(12).6510-21
01 December 2021