FORMULATION AND EVALUATION OF GASTRO RETENTIVE MUCOADHESIVE FILM OF RITONAVIR

Objective: The research work aims to formulate and evaluate the Gastro retentive mucoadhesive film of Ritonavir using polymers like HPMC K15M, Polyvinyl alcohol, and PEG 400 as a plasticizer by solvent casting method for treatment of AIDS. Method: Prepared gastro retentive mucoadhesive films were evaluated for various parameters such as in-vitro unfolding behavior of film, Folding endurance, Percent swelling, Drug content, and in-vitro drug release studies. Results: The release rate of the gastro retentive mucoadhesive films of Ritonavir was found to obey Korsmeyer-Peppas kinetics. After analysis of different evaluation parameters and drug release kinetics. Conclusion: Formulation code F4 was selected as a promising formulation for delivery of Ritonavir as a muco-adhesive Gastro retentive film with required in-vitro parameters 99.08% drug release at 12^th h.