A COMPREHENSIVE REVIEW ON LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM
AbstractLiposome was derived from two Greek words “Lipos” meaning fat, and “Soma” meaning body. Liposome, where spherical-shaped vesicles consist of phospholipids and cholesterol vesicles which are under extensive investigation as drug carriers for improving the bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome-based drug delivery systems are currently in a clinical trial, and recently some of them have been approved for clinical use. Due to their size, hydrophobic and lipophilic character, they are up-and-coming systems for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are biocompatible and stable They have the unique property to entrap both hydrophilic drug and lipophilic drug (amphipathic nature) to its compartment and lead to a controlled-release effect. They are 0.05to 5micrometertre in diameter. Liposomes are used for the treatment of various diseases like tumours or cancer. This review describes the current state-of-the-art of these new liposomal delivery systems classification, formulation, characterization, and potential applications of liposomes in drug delivery.
Article Information
15
628-644
2641 KB
1870
English
IJPSR
R. Divyasree *, K. Divya, S. Aarti, K. Bhavani, M. Vamsidhar, S. B. Bhanja, M. Sudhakar and B. B. Panigrahi
Department of Pharmaceutics, Malla Reddy College of Pharmacy, (Affiliated to Osmania University), Maisammaguda, Hyderabad, Telangana State, India.
satyabrata_bhanja@rediffmail.com
14 March 2021
15 June 2021
28 June 2021
10.13040/IJPSR.0975-8232.13(2).628-44
01 February 2022
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