QUINAZOLINE HETEROCYCLE AND ITS ANTI-CANCER ACTIVITY: AN OVERVIEW

The aim of this review is to provide an extensive overview of the diverse pharmacological activities of quinazoline moiety. Quinazolines are well-known and important nitrogen-containing heterocyclic compounds made chemical formula C₈H₆N₂. For the last few years, the heterocyclic fused nucleus quinazoline has drawn immense attention due to its diversified application in medicinal chemistry research. In the growing world of intense research, Quinazoline was considered as a privileged scaffold; the modification made with different substituents around the centroid paved the researchers away to deal with at ease. Being a fused ring, the heterocycle itself is capable of great pharmacological quality. Quinazoline is one of the heterocycles with diversifying scaffolds for various important biological activities for which considerable research has been done in order to examine its biomedical applications. In a number of biologically active compounds and drug molecules, the quinazoline nucleus is used as a basic framework. This paper is a sincere attempt to highlight the tremendous potential of this ring system because of its wide spectrum of pharmacological actions. This study can also speed up the design and synthesis process in order to create more therapeutically viable clinical candidates.