STUDIES ON SOLID DISPERSION OF CURCUMIN USING HYDROPHILIC POLYMER WITH SYLOID XDP AND LOZENGE CHARACTERIZATION

Curcumin, an active phytochemical compound of the rhizome Curcuma longa, shows several pharmacological activities. Curcumin shows high permeability and low dissolution rate, and its incomplete absorption leads to very poor oral bioavailability. The present study aimed to enhance curcumin’s solubility and dissolution rate by forming internal ternary solid dispersion using hydrophilic polymer PVP K30 and water-insoluble surface modifying carrier Syloid XDP in a weight ratio of 1:3:2, 1:3:3, 1:1:3, and 1:2:2 for curcumin: PVP K30: Syloid XDP. Saturation solubility of internal ternary solid dispersion showed many folds increase in solubility as compared to plain curcumin in water, pH 1.2, 4, 6.8, and 7.4. Lozenges prepared from internal ternary solid dispersion showed excellent solubility and dissolution comparable with the marketed product. The lozenges exhibited improved antibacterial activity and rapid drug dissolution for a prolonged period of time. Therefore, they can be a promising alternative to the marketed product as immunity booster, anti-inflammatory, and oral hygiene. The study suggests that internal ternary solid dispersion of curcumin prepared using PVPK30 and Syloid XDP can be used to improve solubility and dissolution desired for bio enhancement.