AN OVERVIEW ON PARKINSON’S DISEASE ANIMAL MODELS: FROM CLASSIC TO EVOLVING

A progressive neurodegenerative brain disorder with motor & non-motor are signs of Parkinson’s disease or idiopathic parkinsonism. Parkinsonism is characterized in striatal region by the deterioration of Substantia nigra pars compacta & dopamine depletion in Dopaminergic neurons. In Parkinsonism research, the prime purpose is to recognize the pathogenesis, strategies & implementation of therapeutic frameworks that regulate the disease progress. Versions of toxins are even starting to be used to anticipate what might arise in individual Parkinson’s disease. There is indeed, ton of advancement to be developed especially with reference to the design of experimental models which can precisely determine productive clinical neuroprotective substances. For Parkinsonism research, modern pharmacological, neurotoxin-induced, genetically altered & cellular models become presently accessible. Although caution should be exercised in the initial detection of neurodegenerative illnesses, data imply that future progress is secure, possible and probable to boost clinical care. In this overview, comprehensive information on key features of in-vivo & in-vitro models presently available has been included.