FORMULATION AND EVALUATION OF CANDESARTAN CILEXETIL LOADED SOLID LIPID NANOPARTICLES WITH IMPROVED BIOAVAILABILITY
AbstractIn this present work, BCS class II Candesartan celexitil, as an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure, was successfully loaded in the solid lipid nanoparticles (SLNs) by using hot high-speed homogenization method. The SLN formulations were prepared and optimized by Box Benhken design study. The SLN was characterized by Nanophox size analyzer and Delsa nano C zetameter. The SLN was also evaluated for particle size, zeta potential, entrapment efficiency, drug loading, surface morphology, and in-vitro dissolution study. The average particle size, zeta potential, percentage entrapment efficiency, and drug loading were found to be 177nm, -8.23 mV, 95.72 %, and 8.23 %, respectively. The dissolution study of SLN showed 92.07 % released in six hours compared to 46.89% release from the pure drug, which indicates a significant improvement in the bioavailability. The release of the drug from SLN showed zero-order kinetics. The stability study was also carried out and found to be stable after three months.
Article Information
20
1616-1623
1468 KB
448
English
IJPSR
U. S. Bagul *, A. A. Tagalpallewar and A. A. Kshirsagar
Department of Pharmaceutics, Sinhgad Technical Education Society, Narhe, Pune, Maharashtra, India.
usbagul.siop@yahoo.in
18 June 2019
03 March 2022
21 March 2022
10.13040/IJPSR.0975-8232.13(4).1616-23
01 April 2022
Download