IN-VITRO ANTIDIABETIC AND ANTIOXIDANT ACTIVITIES OF AQUEOUS AND ETHANOLIC EXTRACT OF VITIS VINIFERA SEEDS
AbstractIn the present study, the aqueous and ethanolic extracts of Vitis vinifera seeds were studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The plant extracts were also examined for their antioxidant activities by using the free radical 1, 1-diphenyl-2-picryl hydrozyl (DPPH) scavenging method under in-vitro. The study revealed that the different concentrations of the extract possessed a very good amount of result and exhibited potent radical scavenging activity using DPPH SA substrate. The aqueous (68.5%) and ethanolic extract (74.2%) of Vitis vinifera seeds showed a significant inhibitory effect on alpha-amylase activity ethanol extract (74.2%), aqueous extract (68.5%). In the alpha-glucosidase activity ethanolic extract (75.7%) and aqueous extract (74.5%) showed a significant inhibitory effect when compared with standard acarbose drugs. Therefore, it is suggested that the aqueous and ethanolic extract of Vitis vinifera seeds could be used as a potential source for natural anti-diabetic and antioxidant compounds and could have the potential use in the management of diabetes mellitus and hyperglycemia.
Article Information
36
1765-1770
605 KB
411
English
IJPSR
R. Gomathi *, K. Nithyasri, J. Roshika, K. Subhapathi and P. Priyadharshini
Department of Biochemistry, Holy Cross College, Tiruchirappalli, Tamil Nadu, India.
gomathi.biochemistry@gmail.com
02 July 2021
14 August 2021
21 August 2021
10.13040/IJPSR.0975-8232.13(4).1765-70
01 April 2022
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