ANTI-CANCER EFFECT OF PANCHAGAVYA ON HUMAN COLON ADENOCARCINOMA (HCT-116) CELL LINE
AbstractThe objective of the study was to investigate the in-vitro anti-cancer effect of Panchagavya on the Human Colon Adencarcinoma (HCT-116) cell line. Panchayavya was formulated using five products from Cows, namely; Cow dung, Cow urine, Cow milk, Cow curd and Cow ghee. The whole mixture was further freeze-dried and stored until further assay conduction. The growth inhibitory activity of the raw Panchagavya (PGS1) and formulated Panchagavya (PGS2) in HCT-116 colon cancer cells were investigated by 3-(4, 5 – dimethyl thiazolyl – 2) – 2, 5-diphenyl-tetrazolium bromide (MTT) assay. The results from MTT assay indicated that cell proliferation was significantly (p <0.05) inhibited in a concentration-dependent fashion, especially by formulated Panchagavya. Thus, Panchagavya formulation has a potential anti-cancer activity. In this context, we investigated the anti-proliferative potential of Fresh Panchgavya preparation against the Human Colon Adenocarcinoma (HCT-116) Cell Line. To the best of our knowledge, this is the first report demonstrating in-vitro anti-proliferative efficacy of Panchgavyaagainst Human Colon Adenocarcinoma (HCT-116) Cell Line.
Article Information
37
1771-1776
761 KB
730
English
IJPSR
S. Funde, S. Patil * and H. Palep
Principal K. M. Kunanani College of Pharmacy, Mumbai, Maharashtra, India.
snehalfundecogno@gmail.com
18 February 2022
21 March 2022
30 March 2022
10.13040/IJPSR.0975-8232.13(4).1771-76
01 April 2022
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