SYNTHESIS AND ANTI-CONVULSANT ACTIVITY OF NOVEL BENZHYDRYL PIPERAZINE DERIVATIVES
AbstractA series of 1 – (4 -Benzhydryl piperazin-1-yl) -3-(mono -substituted) propan-1-one (7c-i) and N – (substituted) – 2 – (4 –benz-hydrylpiperazin – 1 – yl) acetamide (7a, 7d) were designed, synthesized and evaluated for their anticonvulsant and neurotoxicity activity. The chemical structure of the synthesized compounds was elucidated by spectral and elemental analysis. Compounds like 7d, 7c, and 7g showed good anticonvulsant activity and less neurotoxicity. Compounds 7a, 7c, 7f and 7l produce more neurotoxicity and also have less protection against convulsive stimuli than the other compounds.
Article Information
38
1777-1784
592 KB
552
English
IJPSR
Kuldeep Singh *, Ashok K. Shakya, Shashi Alok, Rajashri R. Naik and Arun Kumar
Faculty of Pharmacy, Integral University Kursi Road, Lucknow, Uttar Pradesh, India.
kuldeep@iul.ac.in
18 February 2022
23 March 2022
30 March 2022
10.13040/IJPSR.0975-8232.13(4).1777-84
01 April 2022
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