RESEALED ERYTHROCYTES AS A NOVEL CARRIER FOR DRUG DELIVERY: A REVIEW

Drug delivery systems including chemical, physical and biological agents that can enhance the bioavailability, improve pharmacokinetics and reduce toxicities of the drugs. Carrier erythrocytes are one of the most promising biological drug delivery systems investigated in recent decades. Resealed Erythrocytes are biocompatible, biodegradable, possess long circulation half-life and can be loaded with variety of active drug substances. Resealed erythrocyte has got several advantages over the other drug delivery system which makes it superior than other systems. Carrier erythrocytes are prepared by collecting blood sample from the organism of interest and separating erythrocytes from plasma. By using various methods, the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called “resealed erythrocytes”. Resealed erythrocytes, as a drug delivery system has excellent capacity to enhance the therapeutic index and patient compliance. It has got tremendous potential to achieve site specific drug delivery with least wastage of drugs and it also prolong the release of drug. So many drugs like aspirin, steroid, cancer drug which having many side effects are reduce by resealed erythrocyte. The present review signifies various features, drug loading methods and applications of resealed erythrocytes.