ANTIOXIDANT AND ANTICANCER ACTIVITIES OF ETHANOLIC EXTRACT OF FICUS GLOMERATA ROXB. IN DMBA INDUCED RATS

The present study was designed to evaluate the antioxidant and anticancer activities of the ethanolic leaf extract of Ficus glomerata Roxb. on the basis of enzymatic and non-enzymatic antioxidants, xenobiotic enzymes and histopathological parameters in 7, 12- dimethylbenz(a)anthracene (DMBA) induced mammary carcinoma in rats. F. glomerata is large evergreen tree, found all over India and South East Asia. DMBA at a dose of 20mg/kg body weight (gastric intubation) significantly reduce the enzymatic antioxidant  such as superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione peroxidase (GPX), glutathione reductase (GR), glucose-6-phosphate-dehydrogenase (G6PD) and non-enzymatic antioxidant like vitamin-C, vitamin-E and total reduced glutathione (TRG) and lipid peroxidation (LPO) in group II rats. A significant increase in xenobiotic enzymes like cytochrome P₄₅₀ and cytochrome b₅, in DMBA induced groups were observed. Treatment with ethanolic leaf extract of F. glomerata (150mg/kg body weight, orally) in group III rats were observed all these above mentioned parameters were reverted to near normal level when compared to control rats. Finally, we concluded that the F. glomerata leaf extract exerts equipotent anticancer and antioxidant activities in the experimental model of DMBA induced mammary carcinoma in rats.