FORMULATION AND DEVELOPMENT OF LIPOSOMAL DELIVERY OF ANTICELLULITE

Aim: Cellulite treatment incorporates iso-slim complex to reload the skin with minerals and trace elements to achieve absolute effectiveness in treating cellulite condition. The revitalizing effect of anticellulite helps  to  refine  and  reshape  the  silhouette  and  give  the  body  a  more  toned,  defined  and firmer appearance. Aim of present work was to develop and investigate a novel delivery system for the fatty skin in the form of liposome delivery system.

Method: Phosphatidylcholine, Cholesterol  and iso-slim complex  were  dissolved  in chloroform/methanol  (2:1, v/v)  mixture  and subsequently  transferred into  a  pear-shaped  flask connected to a Rotavapor (Buchi- type). Rotary evaporation method was used for the formulation of liposomes.

Result: Liposome prepared was evaluated for particle size measurement, percent drug entrapment, formulation of dosage forms, Stability Study and in vivo study. Optimized batch had particle size 18.62 um, percent drug entrapment 96.70%. Hence, optimized was batch further evaluated for in vivo study and stability study.

Conclusion: The present study has been a satisfactory attempt to formulate and evaluate liposome of iso-slim complex and liposomal gel with a providing sustained delivery of drug. The liposome made by iso-slim complex with lecithin and stearic acid found better effect on the skin. Drug loaded liposome have great penetration power and deposited in deeper layer of the skin.The main aspect for this preparation is to reduce the fat from the skin.