FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACETAMINOPHEN
AbstractThe present research work has been carried out for an optimized formulation of co-processed directly compressible vehicles in the preparation of the Acetaminophen mouth fast dissolving tablets (MFDTs). Acetaminophen was chosen due to its poor compression properties. Di-calcium Phosphate(DCP) was incorporated in the neutralized aqueous starch dispersion to prepare co-processed excipient. Co-processed direct compressible DCP and Starch used as co-processed excipient were taken in good formulation ratio such as (25:75) and Cross Povidone used as superdisintegrant. The effects of other superdisintegrants were studied in the best formulation F5. Formulation F5 was found to be optimum compressibility characteristics hardness 3.62±0.40 to 4.68±0.31 kg/cm2 with fast disintegration (10 sec) compare to other formulations
Article Information
48
610-614
449KB
1595
English
IJPSR
Abhay Kumar Mourya*, Sunil K. Prajapati , S.K. Jain , Ajay Kumar, Atul Kumar Thakran and Shashi Alok
Institute of Pharmacy, Bundelkhand University,Jhansi, Uttar Pradesh, India
27 September, 2011
13 November, 2011
17 January, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).610-14
1-February-2012
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