TELMISARTAN NIOSOMES DESIGN, DEVELOPMENT AND CHARACTERIZATION
AbstractTelmisartan has a strong, nonpeptide antagonist with long-acting angiotensin II type-1 (AT 1) receptor to treat essential hypertension. It is classified as a BCS class II medication, meaning it has poor solubility and high permeability. Because of their capacity to minimise toxicity and change bioavailability, niosomes are becoming increasingly essential in medication delivery. Telmisartan-loaded niosomes were created by adjusting the span 60 and cholesterol ratios in a thin film hydration technique and then assessed for vesicles size, entrapment efficiency and drug release. Batch N6 fulfilled all the requirements and hence it was selected as an optimized formulation of noisome. This investigation supports the use as carriers for developed niosomes to enhance the administration of Telmisartan by oral route.
Article Information
16
3535-3542
1051 KB
451
English
IJPSR
V. V. Gurav *, S. S. Hande, A. V. Desai, V. Y. Rohile, N. R. Inamdar and S. S. Upadhye
Dnyanvilas College of Pharmacy, Dudulgaon, Pune, Maharashtra, India.
vaishnavig8329@gmail.com
05 January 2022
05 April 2022
26 April 2022
10.13040/IJPSR.0975-8232.13(9).3535-42
01 September 2022
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