FREE RADICAL SCAVENGING POWER POTENTIATES ANALGESIC, ANTI-INFLAMMATORY AND CNS DEPRESSANT ACTIVITY OF ALANGIUM SALVIIFOLIUM WANG

Alangium salviifolium wang. Family Alangiaceae used as a traditional medicinal plant. The objective of this study was to evaluate the comparative phytochemical and in-vitro antioxidant activity along with analgesic, anti-inflammatory, and central nervous system (CNS) depressant activities of peel and seed extract of Alangium salviifolium fruit. Quantitative phytochemical analysis for total phenolic and flavonoid content measured by Folin-Ciocalteu and Aluminium chloride method was maximum for peel (104.03 ± 0.40 mg of GAE /gm and 34.33 ± 0.24 mg of CAE /gm of dried extract respectively. In the DPPH assay method, total antioxidant capacity and reducing power assay showed significant (P< 0.05) antioxidant activity based on IC₅₀ value. Peel extract significantly (P< 0.01) inhibited writhing (44.44 %) induced by acetic acid in mice compared to seed (37.45 %). The anti-inflammatory activity measured by the carrageenan-induced mice paw edema method was observed to be significant (P< 0.01, P< 0.05) at 2^nd, 3^rd and 4^th hour. The percent inhibition of peel and seed was 34.97% and 35.50%, which was very close to standard Ibuprofen (37.80%). Our investigation also revealed a significant reduction of locomotor activity of mice in open field and hole cross test compared to standard diazepam. A significant (P< 0.01, P< 0.05) decline in locomotion at the doses of 75 mg/kg for peel and seed (6 ± 1 and 0) after 120 min which was less than the standard (8.33±0.33). It could be accomplished that A. salviifolium may be a promising source of natural antioxidant that potentiate different pharmacological actions.