PREPARATION AND EVALUATION OF LIPID MICROSPHERE OF VERAPAMIL HYDRO-CHLORIDE

Microspheres drug delivery system have improved patient compliance, decreased toxicity, and increased efficacy. This work aimed to design a controlled-release drug-delivery system for lipid microspheres of Verapamil hydrochloride that would retain the drug in the stomach and continuously release the drug in a controlled manner up to a predetermined time. Lipid microspheres were prepared by using a melt solidification method. Microspheres with spherical shapes and narrow size distribution were formed. In the present investigation, two lipids were used in various concentrations; Ceresine wax & Bees Wax. In-vitro performance was evaluated, such as particle size analysis, drug entrapment efficiency, compatibility study, Preformulation study, flow properties, in-vitro drug release studies, stability studies, etc. The drug in microspheres was found to be stable and compatible with waxes, as confirmed by DSC and FTIR methods. The mixing ratio of lipids with drug affected the size, size distribution, Yield, drug content, and drug release of microspheres. Results showed that the solid, discrete, reproducible free-flowing microspheres were obtained. In most cases, good in-vitro microsphere behavior was observed, and a broad variety of drug release patterns could be achieved by variation of the drug-lipid ratio. The release kinetics followed different transport mechanisms. The surface morphology of microspheres was characterized by scanning electron microscopy (SEM). The release of the drug was controlled for more than 12h.